SCHEMBL7530416

SCHEMBL7530416

C=CC(=O)NC(=O)c1cccnc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.59
HDAC6 Q9UBN7 1/20 0.59
LMNA P02545 2/20 0.54
THRB P10828 1/20 0.54
HIF1A Q16665 1/20 0.54
FTO Q9C0B1 1/20 0.54
ROCK2 O75116 1/20 0.53
ROCK1 Q13464 1/20 0.53
GAA P10253 4/20 0.52
CYP2C9 P11712 2/20 0.52
HTT P42858 1/20 0.52
ALPL P05186 1/20 0.52
ALPI P09923 1/20 0.52
ALPG P10696 1/20 0.52
ALDH1A1 P00352 3/20 0.51
KDM4E B2RXH2 1/20 0.51
APP P05067 1/20 0.50
HCAR3 P49019 1/20 0.50
HCAR2 Q8TDS4 1/20 0.50
CYP2C19 P33261 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2000041 0.84 HDAC1 (0.74) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL155299 0.79 HDAC1 (0.62) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL29011921 0.79 GAA (0.71) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL5793445 0.79 HDAC1 (0.67) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL2931801 0.78 AKT1 (0.54) HDAC1HDAC6LMNAGAAALDH1A1
SCHEMBL19981101 0.78 HDAC1 (0.61) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL9118071 0.77 HDAC1 (0.65) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL2488253 0.77 HDAC1 (0.65) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL8559227 0.77 ALDH1A1 (0.78) HDAC1HDAC6LMNAFTOGAA
SCHEMBL1583591 0.77 ALDH1A1 (0.59) HDAC1HDAC6LMNAGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002030466-A2 PHARMACEUTICAL APPLICATIONS OF HYDROTROPIC AGENTS, POLYMERS THEREOF, AND HYDROGELS THEREOF PURDUE RESEARCH FOUNDATION (US) 2002-04-18 WO disclosed