Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536631 | 0.89 | CASP3 (0.47) | EGFRALDH1A1CYP3A4KDM4EHSD17B10 | |
| SCHEMBL7260644 | 0.87 | EGFR (0.50) | EGFRALDH1A1CYP3A4KDM4EHSD17B10 | |
| SCHEMBL7257558 | 0.86 | TSPO (0.45) | EGFRALDH1A1CYP3A4KDM4EHSD17B10 | |
| SCHEMBL7256749 | 0.84 | ALDH1A1 (0.48) | EGFRALDH1A1CYP3A4KDM4EHSD17B10 | |
| SCHEMBL7261259 | 0.84 | EGFR (0.48) | EGFRALDH1A1CYP3A4KDM4EHSD17B10 | |
| SCHEMBL7531263 | 0.82 | PTGS2 (0.45) | EGFRALDH1A1CYP3A4KDM4EHSD17B10 | |
| SCHEMBL7257604 | 0.82 | ALDH1A1 (0.46) | EGFRALDH1A1CYP3A4KDM4EHSD17B10 | |
| SCHEMBL7260717 | 0.82 | ALDH1A1 (0.48) | EGFRALDH1A1CYP3A4KDM4EHSD17B10 | |
| SCHEMBL7530216 | 0.81 | PTGS2 (0.44) | ALDH1A1CYP3A4KDM4EHSD17B10NPC1 | |
| SCHEMBL7261248 | 0.80 | ALDH1A1 (0.46) | EGFRALDH1A1CYP3A4KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202971-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING 4-QUINOLONES | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | disclosed |
| WO-2002022074-A2 | USE OF 2- AND 4- QUINOLONES FOR INHIBITING INTIMAL NEO-PROLIFERATION | LABORATOIRE L. LAFON (FR) | 2002-03-21 | — | — | WO | disclosed |
| WO-2001012607-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING 4-QUINOLONES FOR TREATING CANCERS | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | disclosed |