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SCHEMBL7532812

SCHEMBL7532812

Cc1ccccc1S(=O)(=O)Nc1cc(-c2cccs2)sc1C(=O)Nc1cccc(Cl)c1.Cc1csc(C(=O)Nc2cccc(Cl)c2)c1NS(=O)(=O)c1ccc(Cl)cc1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.47
▸ MEN1 O00255 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ IDH1 O75874 4/20 0.42
▸ GPR27 Q9NS67 2/20 0.42
▸ LMNA P02545 2/20 0.41
▸ HTT P42858 1/20 0.41
▸ RECQL P46063 1/20 0.41
▸ KDM4E B2RXH2 1/20 0.40
▸ GAA P10253 1/20 0.39
▸ ACLY P53396 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7532017 0.90 MAPT (0.57) MAPTMEN1KMT2AMAPK1IDH1
SCHEMBL7537898 0.83 GPR27 (0.54) MAPTMEN1KMT2AMAPK1IDH1
SCHEMBL7561597 0.79 GPR27 (0.54) MAPTMEN1KMT2AMAPK1IDH1
SCHEMBL7537162 0.76 MAPT (0.57) MAPTMEN1KMT2AMAPK1IDH1
SCHEMBL2157542 0.74 NPSR1 (0.46) KMT2AKDM4EACLY
SCHEMBL7537677 0.73 KMT2A (0.59) MAPTMEN1KMT2AIDH1GPR27
SCHEMBL2158668 0.71 ACLY (0.67) KDM4EACLY
SCHEMBL7534435 0.70 MEN1 (0.47) MAPTMEN1KMT2AMAPK1IDH1
SCHEMBL2157930 0.69 ACLY (0.55) KDM4EACLY
SCHEMBL7531361 0.69 L3MBTL1 (0.53) MAPTMEN1KMT2AMAPK1IDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002028353-A2 PHOSPHATE TRANSPORT INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2002-04-11 — — WO claimed