SCHEMBL7534253

SCHEMBL7534253

Cc1c(N)ccc(O)c1N(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.40
ALOX15 P16050 4/20 0.40
HSD17B10 Q99714 3/20 0.40
TSHR P16473 3/20 0.37
CYP3A4 P08684 2/20 0.37
PIK3CA P42336 1/20 0.37
ESR1 P03372 3/20 0.37
ESR2 Q92731 2/20 0.37
EP300 Q09472 2/20 0.35
KAT2B Q92831 2/20 0.35
KAT8 Q9H7Z6 2/20 0.35
HDAC3 O15379 1/20 0.35
IDO1 P14902 1/20 0.35
NCOR2 Q9Y618 1/20 0.35
PDE10A Q9Y233 1/20 0.35
CSNK2A2 P19784 1/20 0.34
CSNK2B P67870 1/20 0.34
CSNK2A1 P68400 1/20 0.34
CSNK2A3 Q8NEV1 1/20 0.34
AR P10275 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4652973 0.78 S100B (0.43) ALDH1A1ALOX15HSD17B10TSHRCYP3A4
SCHEMBL3965959 0.77 TRPA1 (0.41) ALDH1A1ALOX15HSD17B10TSHRCYP3A4
SCHEMBL533217 0.77 CYP3A4 (0.40) ALDH1A1ALOX15HSD17B10TSHRCYP3A4
SCHEMBL5804367 0.74 CA3 (0.33) ALDH1A1ESR1ESR2EP300KAT2B
SCHEMBL525507 0.74 ALDH1A1 (0.48) ALDH1A1ALOX15HSD17B10TSHRCYP3A4
SCHEMBL291343 0.72 ALDH1A1 (0.46) ALDH1A1ALOX15HSD17B10TSHRCYP3A4
Hydrochloric Acid SCHEMBL5204358 0.72 ALDH1A1 (0.46) ALDH1A1ALOX15HSD17B10TSHRCYP3A4
SCHEMBL1568810 0.72 ALDH1A1 (0.52) ALDH1A1ALOX15HSD17B10TSHRCYP3A4
Hydrochloric Acid SCHEMBL27495760 0.70 ALDH1A1 (0.50) ALDH1A1ALOX15HSD17B10TSHRCYP3A4
SCHEMBL8111492 0.70 CHEK1 (0.45) ALDH1A1ALOX15HSD17B10TSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1194116-A1 AGENT FOR DYEING FIBRES CONTAINING KERATIN Henkel Kommanditgesellschaft auf Aktien (DE) 2002-04-10 EP claimed
WO-2001003660-A1 AGENT FOR DYEING FIBRES CONTAINING KERATIN HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2001-01-18 WO claimed
EP-0226072-B1 OXIDATION DYE CONTAINING 4-AMINO-2-AMINOMETHYL PHENOL Wella Aktiengesellschaft (DE) 1991-04-10 EP disclosed