⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3036337 | 0.71 | ALDH1A1 (0.30) | — | |
| SCHEMBL30528370 | 0.62 | POLB (0.50) | — | |
| SCHEMBL15059410 | 0.62 | POLB (0.50) | — | |
| SCHEMBL4790338 | 0.62 | TSHR (0.31) | — | |
| SCHEMBL14743144 | 0.61 | LMNA (0.56) | — | |
| SCHEMBL7701538 | 0.59 | ALDH1A1 (0.46) | — | |
| SCHEMBL29723856 | 0.59 | MLYCD (0.46) | — | |
| SCHEMBL2037036 | 0.58 | ALDH1A1 (0.44) | — | |
| SCHEMBL340272 | 0.58 | ALDH1A1 (0.70) | — | |
| SCHEMBL28176547 | 0.58 | POLB (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | disclosed |
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | AMGEN INC. (US) | 2012-07-26 | — | — | US | disclosed |
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | disclosed |