Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 11/20 | 0.62 |
| ▸ | DRD2 known ✓ | P14416 | 11/20 | 0.62 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | HTR1D | P28221 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9764481 | 1.00 | OPRM1 (0.65) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL7536094 | 0.80 | OPRM1 (0.78) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL373815 | 0.80 | HTR1A (0.71) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL14280720 | 0.79 | OPRM1 (1.00) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL13944353 | 0.79 | DRD2 (0.79) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL9527241 | 0.78 | OPRM1 (0.78) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL7543848 | 0.78 | HTR1A (1.00) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL1122147 | 0.76 | OPRM1 (0.71) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL3341152 | 0.76 | SLC6A4 (0.68) | — | |
| SCHEMBL8555542 | 0.76 | TDP1 (0.71) | HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1131174-A | — | — | None | — | — | JP | disclosed |
| US-5066660-A | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1991-11-19 | — | — | US | disclosed |
| JP-H01131174-A | INDOLE DERIVATIVE | GLAXO GROUP LTD | 1989-05-24 | — | — | JP | disclosed |
| EP-0303506-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |