SCHEMBL7537229

SCHEMBL7537229

COc1ccc2oc(C(=O)NC3(C(=O)NCCCCC(=O)c4nc5ccccc5o4)CCCCC3)cc2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 2/20 0.49
HDAC1 Q13547 2/20 0.49
HDAC2 Q92769 2/20 0.49
HDAC4 P56524 1/20 0.49
HDAC7 Q8WUI4 1/20 0.49
HDAC10 Q969S8 1/20 0.49
HDAC11 Q96DB2 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
HDAC9 Q9UKV0 1/20 0.49
HDAC5 Q9UQL6 1/20 0.49
TACR2 P21452 2/20 0.45
BCHE P06276 7/20 0.42
ACHE P22303 7/20 0.42
APP P05067 1/20 0.42
BACE1 P56817 1/20 0.42
TAS1R3 Q7RTX0 5/20 0.41
TAS1R1 Q7RTX1 5/20 0.41
FAAH O00519 1/20 0.41
CES1 P23141 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7531275 0.90 TACR2 (0.49) HDAC3HDAC1HDAC2HDAC4HDAC7
SCHEMBL7531990 0.82 ALDH1A1 (0.45) HDAC3HDAC1HDAC2HDAC4HDAC7
SCHEMBL7533012 0.79 FAAH (0.45) HDAC6FAAHCES1DAGLA
SCHEMBL7529866 0.79 FAAH (0.43) HDAC6TACR2FAAHCES1DAGLA
SCHEMBL7530247 0.79 FAAH (0.44) HDAC3HDAC1HDAC6FAAHCES1
SCHEMBL7535950 0.78 CTSL (0.49) HDAC3HDAC1HDAC2HDAC4HDAC7
SCHEMBL7528389 0.78 MAPT (0.42) TACR2FAAHCES1DAGLAKMT2A
SCHEMBL7530297 0.78 CTSL (0.42) HDAC3HDAC1HDAC6FAAHCES1
SCHEMBL7533880 0.78 TACR2 (0.52) TACR2
SCHEMBL7530914 0.77 FAAH (0.43) HDAC3HDAC1FAAHCES1DAGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002023784-A2 CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-03-21 WO claimed
WO-2002023784-A2 CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-03-21 WO disclosed