SCHEMBL7537945

SCHEMBL7537945

COC(=O)c1sccc1NC(=O)c1sccc1NS(=O)(=O)c1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.67
LMNA P02545 3/20 0.67
TSHR P16473 1/20 0.67
L3MBTL1 Q9Y468 1/20 0.64
SMN1; SMN2 Q16637 5/20 0.59
SLC10A6 Q3KNW5 1/20 0.58
NPSR1 Q6W5P4 3/20 0.56
KDM4E B2RXH2 3/20 0.56
ALDH1A1 P00352 4/20 0.56
KMT2A Q03164 4/20 0.56
MAPT P10636 3/20 0.56
MEN1 O00255 2/20 0.56
CYP1A2 P05177 1/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
MAPK10 P53779 3/20 0.54
POLB P06746 1/20 0.54
MAPK8 P45983 1/20 0.54
MAPK9 P45984 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL532885 0.92 LMNA (0.78) HPGDLMNATSHRL3MBTL1SMN1; SMN2
SCHEMBL7538971 0.86 KMT2A (0.57) HPGDLMNATSHRL3MBTL1SMN1; SMN2
SCHEMBL7531858 0.86 KMT2A (0.55) HPGDLMNATSHRL3MBTL1SMN1; SMN2
SCHEMBL7530810 0.85 ALDH1A1 (0.58) HPGDLMNATSHRL3MBTL1SMN1; SMN2
SCHEMBL7532088 0.84 CYP2C9 (0.60) HPGDLMNATSHRL3MBTL1SMN1; SMN2
SCHEMBL7533940 0.83 RAB9A (0.56) HPGDLMNATSHRL3MBTL1SMN1; SMN2
SCHEMBL7534382 0.82 CYP2C9 (0.55) HPGDLMNATSHRL3MBTL1SMN1; SMN2
SCHEMBL2749317 0.82 LMNA (0.62) HPGDLMNATSHRL3MBTL1SMN1; SMN2
SCHEMBL7537973 0.81 LMNA (0.46) HPGDLMNATSHRL3MBTL1NPSR1
SCHEMBL7533306 0.81 KMT2A (0.54) HPGDLMNATSHRSMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002028353-A2 PHOSPHATE TRANSPORT INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2002-04-11 WO disclosed