SCHEMBL7537973

SCHEMBL7537973

Cc1cccc(NC(=O)c2sccc2NS(=O)(=O)c2ccccc2)c1C

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.46
TSHR P16473 2/20 0.46
HPGD P15428 1/20 0.46
MAPT P10636 3/20 0.46
TP53 P04637 2/20 0.46
THRB P10828 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
HTT P42858 3/20 0.45
GAA P10253 3/20 0.45
MEN1 O00255 2/20 0.45
ALDH1A1 P00352 2/20 0.45
KMT2A Q03164 2/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7531707 0.82 RECQL (0.60) LMNATSHRHPGDMAPTHTT
SCHEMBL3973395 0.82 ACLY (0.44) LMNATSHRHPGDMAPTGAA
SCHEMBL7531823 0.81 MAPT (0.55) LMNATSHRHPGDMAPTHTT
SCHEMBL7531858 0.81 KMT2A (0.55) LMNATSHRHPGDMAPTL3MBTL1
SCHEMBL533542 0.81 FFAR4 (0.57) LMNATSHRHPGDMAPTMEN1
SCHEMBL7537945 0.81 HPGD (0.67) LMNATSHRHPGDMAPTL3MBTL1
SCHEMBL3972622 0.81 CASP3 (0.50) LMNAHPGDMAPTHTTMEN1
SCHEMBL7537977 0.81 ACLY (0.52) LMNATSHRHPGDTP53HTT
SCHEMBL3975445 0.80 KMT2A (0.44) LMNATSHRHPGDMAPTL3MBTL1
SCHEMBL7538871 0.80 METAP2 (0.53) LMNATSHRL3MBTL1HTTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002028353-A2 PHOSPHATE TRANSPORT INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2002-04-11 WO claimed
WO-2002028353-A2 PHOSPHATE TRANSPORT INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2002-04-11 WO disclosed