Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 14/20 | 0.44 |
| ▸ | ITGAV | P06756 | 12/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7542370 | 0.80 | BCHE (0.43) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7540177 | 0.77 | ITGAV (0.43) | ITGB3ITGA2BITGAV | |
| SCHEMBL13170299 | 0.71 | ACE (0.46) | ITGB3ITGA2BITGAV | |
| SCHEMBL6869283 | 0.69 | ITGB3 (0.59) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7399998 | 0.69 | ITGB3 (0.51) | ITGB3ITGA2BITGAV | |
| SCHEMBL7401807 | 0.68 | ITGB3 (0.48) | ITGB3ITGA2BITGAV | |
| SCHEMBL7349056 | 0.68 | ITGB3 (0.63) | ITGB3ITGA2BITGAV | |
| SCHEMBL5782856 | 0.67 | ITGB3 (0.45) | ITGB3ITGA2BITGAV | |
| SCHEMBL7399995 | 0.67 | ITGB3 (0.43) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL3268531 | 0.67 | ITGB3 (0.65) | ITGB3ITGA2BITGAVCHRM2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208088-A2 | FLUORENE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GmbH (DE) | 2002-05-29 | — | — | EP | claimed |
| WO-2001010841-A2 | FLUORENE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2001-02-15 | — | — | WO | claimed |
| EP-1208088-A2 | FLUORENE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GmbH (DE) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001010841-A2 | FLUORENE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2001-02-15 | — | — | WO | disclosed |