Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29406550 | 0.83 | KEAP1 (0.64) | KEAP1NFE2L2AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL2566963 | 0.83 | KEAP1 (0.64) | KEAP1NFE2L2AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL29795353 | 0.82 | SLC9A1 (0.46) | KEAP1NFE2L2AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL22666874 | 0.82 | SLC9A1 (0.46) | KEAP1NFE2L2AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL10873823 | 0.81 | KEAP1 (0.62) | KEAP1NFE2L2AKR1C2AKR1C1AKR1C4 | |
| Hydrochloric Acid SCHEMBL10552257 | 0.81 | KEAP1 (0.62) | KEAP1NFE2L2AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL4698225 | 0.80 | SORT1 (0.44) | KEAP1NFE2L2AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL473918 | 0.78 | ALDH1A1 (0.47) | KEAP1NFE2L2ALDH1A1KDM4EMEN1 | |
| SCHEMBL7886393 | 0.76 | KEAP1 (0.43) | KEAP1NFE2L2AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL16879884 | 0.73 | GABRP (0.49) | KEAP1NFE2L2AKR1C2AKR1C1AKR1C4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5364940-A | For treatment of sewage sludge with cultures | LONZA LTD. (CH) | 1994-11-15 | — | — | US | claimed |
| JP-6199797-A | — | — | None | — | — | JP | disclosed |
| WO-2002029021-A2 | BIOTECHNOLOGICAL METHOD FOR PREPARING CARBOXYLIC ACIDS WITH A HYDROXY-NITROGEN HETEROCYCLE | LONZA AG (CH) | 2002-04-11 | — | — | WO | disclosed |
| US-5364940-A | For treatment of sewage sludge with cultures | LONZA LTD. (CH) | 1994-11-15 | — | — | US | disclosed |
| JP-H06199797-A | MICROBIOLOGICAL PROCESS FOR HYDROXYLATING NITROGEN-HETEROCYCLIC-CARBOXYLIC ACID | LONZA AG | 1994-07-19 | — | — | JP | disclosed |
| US-5306630-A | Microbiological process for hydroxylation of nitrogen-heterocyclic-carboxylic acids | LONZA LTD. (CH) | 1994-04-26 | — | — | US | disclosed |
| EP-0225172-A1 | Process for the preparation of 5-chloro and 5-bromo-2-hydroxynicotinicacids | A.H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-10 | — | — | EP | disclosed |