SCHEMBL7540423

SCHEMBL7540423

CCOC(C(=O)OCC(COC(=O)C(OCC)C(O)C(O)C(O)CO)(COC(=O)C(OCC)C(O)C(O)C(O)CO)COC(=O)C(OCC)C(O)C(O)C(O)CO)C(O)C(O)C(O)CO

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
PDE4A P27815 1/20 0.35
TDP1 Q9NUW8 1/20 0.34
USP2 O75604 1/20 0.33
SLCO1B1 Q9Y6L6 1/20 0.33
KDM4E B2RXH2 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5085107 0.85 LMNA (0.39) LMNAL3MBTL1PDE4ATDP1USP2
SCHEMBL961222 0.81 LMNA (0.35) LMNAL3MBTL1PDE4ATDP1USP2
SCHEMBL964815 0.81 LMNA (0.35) LMNAL3MBTL1PDE4ATDP1USP2
SCHEMBL5689033 0.78 LMNA (0.33) LMNAL3MBTL1PDE4ATDP1USP2
SCHEMBL1133839 0.78 PDE4A (0.50) LMNAL3MBTL1PDE4ATDP1USP2
SCHEMBL23357664 0.77 NAAA (0.41) LMNAUSP2KDM4E
SCHEMBL4850735 0.76 LMNA (0.34) LMNAL3MBTL1PDE4ATDP1USP2
SCHEMBL5173596 0.76 PDE4A (0.48) LMNAL3MBTL1PDE4ATDP1USP2
SCHEMBL31083827 0.75 PDE4A (0.52) LMNAL3MBTL1PDE4ATDP1USP2
SCHEMBL3862937 0.75 LMNA (0.48) LMNAL3MBTL1PDE4ATDP1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12221495-B2 Cyclic peptide and a medicament, external preparation and cosmetic comprising said cyclic peptide IGISU CO., LTD. (JP) 2025-02-11 US disclosed
US-12065512-B2 Cyclic peptide and a medicament, external preparation and cosmetic comprising said cyclic peptide IGISU CO., LTD. (JP) 2024-08-20 US disclosed
EP-4014987-A2 CYCLIC PEPTIDE, AND MEDICINE, EXTERNAL PREPARATION AND COSMETIC EACH CONTAINING SAID CYCLIC PEPTIDE Igisu Co., Ltd. (JP) 2022-06-22 EP disclosed
US-20210277062-A9 CYCLIC PEPTIDE AND A MEDICAMENT, EXTERNAL PREPARATION AND COSMETIC COMPRISING SAID CYCLIC PEPTIDE IGISU CO., LTD. (JP) 2021-09-09 US disclosed
US-20200347096-A1 CYCLIC PEPTIDE AND A MEDICAMENT, EXTERNAL PREPARATION AND COSMETIC COMPRISING SAID CYCLIC PEPTIDE IGISU CO., LTD. (JP) 2020-11-05 US disclosed
EP-3305804-A1 CYCLIC PEPTIDE, AND MEDICINE, EXTERNAL PREPARATION AND COSMETIC EACH CONTAINING SAID CYCLIC PEPTIDE Igisu Co., Ltd. (JP) 2018-04-11 EP disclosed
US-20180066020-A1 A CYCLIC PEPTIDE AND A MEDICAMENT, EXTERNAL PREPARATION AND COSMETIC COMPRISING SAID CYCLIC PEPTIDE IGISU CO., LTD. (JP) 2018-03-08 US disclosed
US-6497889-B2 CONTAINING HYDROXYPROLINE COMPOUND KYOWA HAKKO KOGYO CO., LTD. (JP) 2002-12-24 US disclosed
US-20020009472-A1 Cosmetics KYOWA HAKKO BIO CO., LTD. (JP) 2002-01-24 US disclosed
EP-1166767-A2 Skin care product containing hydroxyproline or N-acylated hydroxyproline derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 2002-01-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200347096-A1 CYCLIC PEPTIDE AND A MEDICAMENT, EXTERNAL PREPARATION AND COSMETIC COMPRISING SAID CYCLIC PEPTIDE TSLP, NPR1, VIP LMNA 4657/4885L3MBTL1 4810/4885PDE4A 688/4885
US-20180066020-A1 A CYCLIC PEPTIDE AND A MEDICAMENT, EXTERNAL PREPARATION AND COSMETIC COMPRISING SAID CYCLIC PEPTIDE NPR1, TSLP, FGF1 LMNA 4600/4885L3MBTL1 4822/4885PDE4A 646/4885
US-20210277062-A9 CYCLIC PEPTIDE AND A MEDICAMENT, EXTERNAL PREPARATION AND COSMETIC COMPRISING SAID CYCLIC PEPTIDE TSLP, NPR1, VIP LMNA 4657/4885L3MBTL1 4810/4885PDE4A 688/4885
US-12221495-B2 Cyclic peptide and a medicament, external preparation and cosmetic comprising said cyclic peptide TSLP, NPR1, VIP LMNA 4657/4885L3MBTL1 4810/4885PDE4A 688/4885
US-12065512-B2 Cyclic peptide and a medicament, external preparation and cosmetic comprising said cyclic peptide TSLP, NPR1, VIP LMNA 4657/4885L3MBTL1 4810/4885PDE4A 688/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.