Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 2/20 | 0.34 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28018125 | 0.81 | TNFSF11 (0.38) | CDC7CCNE1CDK2DBF4POLB | |
| SCHEMBL607884 | 0.76 | APLNR (0.40) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6523680 | 0.76 | PLAU (0.46) | POLBLMNACYP1A2SMN1; SMN2SQOR | |
| SCHEMBL7544018 | 0.76 | POLB (0.38) | CDC7CCNE1CDK2DBF4SIRT6 | |
| SCHEMBL30496336 | 0.75 | CDC7 (0.46) | CDC7CCNE1CDK2DBF4SIRT6 | |
| SCHEMBL28711249 | 0.75 | RAB9A (0.36) | SIRT6MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2215923 | 0.75 | CDC7 (0.46) | CDC7CCNE1CDK2DBF4SIRT6 | |
| SCHEMBL29243306 | 0.74 | CCR4 (0.39) | SIRT6POLBNNMT | |
| SCHEMBL28994040 | 0.73 | STING1 (0.39) | CDC7CCNE1CDK2DBF4NNMT | |
| SCHEMBL7599085 | 0.71 | MEN1 (0.45) | CDC7CCNE1CDK2DBF4SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889038-B1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 2002-05-29 | — | — | EP | disclosed |
| EP-0889038-A1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 1999-01-07 | — | — | EP | disclosed |