Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28744936 | 0.68 | CRBN (0.66) | KMT2AHPGDSMN1; SMN2POLBTDP1 | |
| SCHEMBL10105030 | 0.67 | CRBN (0.39) | SMN1; SMN2RXFP1 | |
| SCHEMBL22571159 | 0.67 | ALDH1A1 (0.34) | HPGDPOLBMAPTALDH1A1GAA | |
| SCHEMBL23296150 | 0.67 | PKM (0.45) | KMT2AHPGDSMN1; SMN2POLBPKM | |
| SCHEMBL7830376 | 0.67 | ALDH1A1 (0.47) | KMT2AHPGDSMN1; SMN2PKMMAPT | |
| SCHEMBL11245813 | 0.67 | L3MBTL1 (0.68) | KMT2AHPGDSMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL7834516 | 0.66 | HPGD (0.54) | KMT2AHPGDSMN1; SMN2PKMMAPT | |
| SCHEMBL20577849 | 0.65 | ATM (0.48) | KMT2AHPGDSMN1; SMN2PKMMAPT | |
| SCHEMBL23345942 | 0.65 | PKM (0.43) | KMT2AHPGDSMN1; SMN2POLBPKM | |
| SCHEMBL5330807 | 0.64 | PKM (0.42) | KMT2AHPGDSMN1; SMN2POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165554-A1 | NEW ENDOTHELIN CONVERTING ENZYME INHIBITORS, THEIR PRODUCTION AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000061579-A1 | NEW ENDOTHELIN CONVERTING ENZYME INHIBITORS, THEIR PRODUCTION AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 2000-10-19 | — | — | WO | disclosed |