Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547773 | 1.00 | FBP1 (0.32) | FBP1GPR17KDM4EALDH1A1HPGD | |
| SCHEMBL7550281 | 0.79 | ULK1 (0.35) | FBP1GRIN1 | |
| SCHEMBL7550279 | 0.79 | ULK1 (0.35) | FBP1GRIN1 | |
| SCHEMBL7653241 | 0.76 | ALOX15 (0.36) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7653239 | 0.76 | ALOX15 (0.36) | KDM4EALDH1A1HPGDHSD17B10 | |
| Ethoxycarbonyl Group SCHEMBL27355886 | 0.73 | GPR17 (0.31) | GPR17 | |
| SCHEMBL27343729 | 0.70 | GPR17 (0.32) | GPR17 | |
| Ethoxycarbonyl Group SCHEMBL27343730 | 0.67 | P2RX7 (0.31) | — | |
| SCHEMBL7658321 | 0.66 | ALOX15 (0.41) | — | |
| SCHEMBL7550064 | 0.66 | MAPK14 (0.33) | KDM4EALDH1A1HPGDATMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |