Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | RHEB | Q15382 | 3/20 | 0.31 |
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550279 | 1.00 | ULK1 (0.35) | ULK1GRIN1ALOX15RAB9ARHEB | |
| SCHEMBL7658321 | 0.87 | ALOX15 (0.41) | ULK1ALOX15 | |
| SCHEMBL7547455 | 0.81 | ULK1 (0.41) | ULK1GRIN1ALOX15RHEBNR4A2 | |
| SCHEMBL7547773 | 0.79 | FBP1 (0.32) | GRIN1FBP1 | |
| SCHEMBL7547774 | 0.79 | FBP1 (0.32) | GRIN1FBP1 | |
| SCHEMBL7550428 | 0.76 | ULK1 (0.41) | ULK1GRIN1ALOX15RHEBNR4A2 | |
| Ethoxycarbonyl Group SCHEMBL27343730 | 0.73 | P2RX7 (0.31) | — | |
| SCHEMBL9433015 | 0.69 | GRIN1 (0.66) | ULK1GRIN1ALOX15RHEBNR4A2 | |
| SCHEMBL27343729 | 0.68 | GPR17 (0.32) | — | |
| Ethoxycarbonyl Group SCHEMBL27355886 | 0.67 | GPR17 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |