Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8087823 | 0.84 | HRH3 (0.50) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL29684111 | 0.82 | HRH3 (0.49) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL2940750 | 0.82 | HRH3 (0.49) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL38661680 | 0.81 | HRH3 (0.53) | APAF1CDC25BCASP3SENP8SENP7 | |
| Hydrochloric Acid SCHEMBL3714613 | 0.81 | HRH3 (0.47) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL92726 | 0.81 | HRH3 (0.53) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL9704853 | 0.79 | APAF1 (0.63) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL21047717 | 0.78 | APAF1 (0.47) | APAF1CDC25BCASP3SENP8SENP7 | |
| Pyrimidine SCHEMBL28765153 | 0.76 | BCHE (0.44) | APAF1CDC25BCASP3SENP8SENP7 | |
| Pyrrole SCHEMBL28092910 | 0.76 | HRH3 (0.50) | APAF1CDC25BCASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8319274-A | — | — | None | — | — | JP | disclosed |
| US-20120214798-A1 | Novel Ethanediamone Hepcidine Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-23 | — | — | US | disclosed |
| EP-0737678-B1 | 4-Indolylpiperazinyl derivatives | AMERICAN HOME PROD (US) | 2002-06-19 | — | — | EP | disclosed |
| EP-0737678-B1 | 4-Indolylpiperazinyl derivatives | AMERICAN HOME PROD (US) | 2002-06-19 | — | — | EP | disclosed |
| CN-1034865-C | 2-Aminopyrimidinone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1997-05-14 | — | — | CN | disclosed |
| JP-H08319274-A | 4-INDOLYLPIPERAZINYL DERIVATIVE | AMERICAN HOME PROD CORP | 1996-12-03 | — | — | JP | disclosed |
| EP-0737677-A1 | 4-Indolylpiperazinyl derivates | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-10-16 | — | — | EP | disclosed |
| EP-0737678-A1 | 4-Indolylpiperazinyl derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-10-16 | — | — | EP | disclosed |
| EP-0737678-A1 | 4-Indolylpiperazinyl derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5519025-A | 4-indolylpiperazinyl derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-21 | — | — | US | disclosed |
| US-5486518-A | 4-indolylpiperazinyl derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-23 | — | — | US | disclosed |
| US-5284854-A | Antiserotonin. antihistamine agents; for sleep disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-02-08 | — | — | US | disclosed |
| US-5256659-A | Antiserotonine agents, antihistamines for nervous system disorders or psychological disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-10-26 | — | — | US | disclosed |
| US-5140029-A | Administering for nervous system, sleep or psychotic disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214798-A1 | Novel Ethanediamone Hepcidine Antagonists | HAMP, SLC40A1, FTH1 | APAF1 1600/4885CDC25B 1288/4885CASP3 3896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.