Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.43 |
| ▸ | MMP1 | P03956 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 6/20 | 0.42 |
| ▸ | MMP9 | P14780 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 5/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP12 | P39900 | 2/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | MMP16 | P51512 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7446620 | 0.79 | MMP1 (0.51) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL7511347 | 0.76 | ALDH1A1 (0.50) | MMP13MMP1ALDH1A1POLBMMP2 | |
| SCHEMBL5268183 | 0.71 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL27744904 | 0.71 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL8601705 | 0.71 | MMP13 (0.49) | MMP13MMP1ALDH1A1MMP2MMP9 | |
| SCHEMBL8601707 | 0.71 | MMP13 (0.49) | MMP13MMP1ALDH1A1MMP2MMP9 | |
| SCHEMBL7451162 | 0.70 | MMP9 (0.54) | MMP13MMP1MMP2MMP9 | |
| SCHEMBL7504494 | 0.70 | MMP9 (0.54) | MMP13MMP1MMP2MMP9 | |
| SCHEMBL7862144 | 0.70 | MMP13 (0.48) | MMP13MMP1ALDH1A1MMP2MMP9 | |
| SCHEMBL28010685 | 0.69 | POLB (0.43) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001930-B1 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2002-12-04 | — | — | EP | disclosed |
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |
| US-6235786-B1 | RHEUMATIC DISORDERS; BONE DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-22 | — | — | US | disclosed |