Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 3/20 | 0.72 |
| ▸ | MMP1 | P03956 | 6/20 | 0.71 |
| ▸ | MMP8 | P22894 | 6/20 | 0.71 |
| ▸ | MMP13 | P45452 | 6/20 | 0.71 |
| ▸ | MMP7 | P09237 | 2/20 | 0.71 |
| ▸ | MMP12 | P39900 | 2/20 | 0.71 |
| ▸ | MEP1B | Q16820 | 4/20 | 0.70 |
| ▸ | MMP3 | P08254 | 8/20 | 0.63 |
| ▸ | MMP2 | P08253 | 5/20 | 0.61 |
| ▸ | MMP9 | P14780 | 5/20 | 0.61 |
| ▸ | MMP14 | P50281 | 3/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.61 |
| ▸ | MMP16 | P51512 | 2/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.58 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8001734 | 0.87 | MEP1B (0.81) | BMP1MMP1MMP8MMP13MMP7 | |
| SCHEMBL7109267 | 0.84 | BMP1 (1.00) | BMP1MMP1MMP8MMP13MMP7 | |
| SCHEMBL7348906 | 0.83 | MEP1B (0.86) | BMP1MMP1MMP8MMP13MMP7 | |
| SCHEMBL26776688 | 0.83 | MMP1 (0.81) | BMP1MMP1MMP8MMP13MMP7 | |
| SCHEMBL598146 | 0.83 | MMP3 (0.79) | BMP1MMP1MMP8MMP13MMP7 | |
| SCHEMBL26776708 | 0.82 | MMP1 (0.79) | BMP1MMP1MMP8MMP13MMP7 | |
| SCHEMBL7342151 | 0.81 | MMP1 (0.70) | BMP1MMP1MMP8MMP13MMP7 | |
| SCHEMBL26776651 | 0.81 | MMP13 (0.74) | BMP1MMP1MMP8MMP13MMP7 | |
| SCHEMBL6415304 | 0.81 | BMP1 (0.89) | BMP1MMP1MMP8MMP13MMP7 | |
| SCHEMBL6418955 | 0.80 | MMP1 (0.76) | BMP1MMP1MMP8MMP13MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380219-B1 | FOR THERAPY OF ARTHRITIS, CANCER, TISSUE ULCERATION, RESTENOSIS, PERIDONTAL DISEASE, EPIDERMOLYSIS BULLOSA, SCLERITIS AND OTHER DISEASES CHARACTERIZED BY MATRIX METALLOPROTEINASE ACTIVITY, SEPSIS, SEPTIC SHOCK | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0813520-B1 | ARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES | PFIZER (US) | 2001-12-19 | — | — | EP | disclosed |
| US-6147074-A | Arylsulfonylamino hydroxamic acid derivatives | PFIZER INC (US) | 2000-11-14 | — | — | US | disclosed |
| US-5994351-A | Arylsulfonylamino hydroxamic acid derivatives | PFIZER INC. (US) | 1999-11-30 | — | — | US | disclosed |
| US-5863949-A | Arylsulfonylamino hydroxamic acid derivatives | PFIZER INC (US) | 1999-01-26 | — | — | US | disclosed |
| WO-1996027583-A1 | ARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1996-09-12 | — | — | WO | disclosed |