Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 10/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 3/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK5 | O95279 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | KCNK17 | Q96T54 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765633 | 0.90 | BDKRB1 (0.49) | BDKRB1CNR1CHRM4KCNK3KCNK5 | |
| SCHEMBL754425 | 0.85 | PPARD (0.44) | BDKRB1FAAHTRPV1CHRM4 | |
| SCHEMBL756518 | 0.84 | BDKRB1 (0.39) | BDKRB1CNR1FAAHTRPV1P2RX7 | |
| SCHEMBL14856425 | 0.79 | BDKRB1 (0.48) | BDKRB1FAAHTRPV1 | |
| SCHEMBL185085 | 0.77 | BDKRB1 (0.47) | BDKRB1FAAHTRPV1F10 | |
| SCHEMBL765812 | 0.76 | BDKRB1 (0.63) | BDKRB1F10 | |
| SCHEMBL12239079 | 0.76 | BDKRB1 (0.44) | BDKRB1CNR1 | |
| SCHEMBL756449 | 0.75 | BDKRB1 (0.46) | BDKRB1FAAH | |
| SCHEMBL754249 | 0.75 | BDKRB1 (0.52) | BDKRB1CNR1FAAHTRPV1 | |
| SCHEMBL3727496 | 0.75 | FAAH (0.39) | BDKRB1FAAHTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |
| EP-2188254-A1 | NOVEL BRADYKININ B1-ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009027450-A1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-03-05 | — | — | WO | disclosed |