Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP4 | P55087 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3653447 | 0.85 | CSF1R (0.53) | HDAC1HDAC3HDAC2KMT2AMEN1 | |
| SCHEMBL28954592 | 0.82 | GAA (0.55) | KMT2AHTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL10406072 | 0.81 | KMT2A (0.66) | AQP4LMNAHIF1AROCK2ROCK1 | |
| SCHEMBL3178559 | 0.76 | AQP4 (1.00) | AQP4LMNAHIF1AROCK2ROCK1 | |
| SCHEMBL31659577 | 0.76 | THRB (0.60) | AQP4LMNAHDAC1HDAC3HDAC2 | |
| SCHEMBL1571386 | 0.75 | LMNA (1.00) | LMNAHIF1AROCK2ROCK1KMT2A | |
| SCHEMBL11591966 | 0.75 | LMNA (0.69) | AQP4LMNAHIF1AROCK2ROCK1 | |
| SCHEMBL6642201 | 0.74 | KMT2A (0.67) | LMNAHIF1AROCK2ROCK1HDAC1 | |
| SCHEMBL3178619 | 0.74 | NPC1 (0.72) | AQP4LMNAHIF1AKMT2AMEN1 | |
| SCHEMBL2000041 | 0.74 | HDAC1 (0.74) | LMNAHIF1AROCK2ROCK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259487-A1 | 2-AMINO-NICOTINAMIDE DERIVATIVES AND THEIR USE AS VEGF-RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2002-11-27 | — | — | EP | claimed |
| WO-2001055114-A1 | 2-AMINO-NICOTINAMIDE DERIVATIVES AND THEIR USE AS VEGF-RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2001-08-02 | — | — | WO | claimed |