Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313495 | 0.95 | F11 (0.46) | F11RXRATDP1CRHR1P2RX3 | |
| SCHEMBL6314138 | 0.94 | F11 (0.45) | F11RXRATDP1CRHR1 | |
| SCHEMBL6313995 | 0.93 | RXRA (0.52) | RXRATDP1HSP90AA1NPSR1KDM4E | |
| SCHEMBL6307883 | 0.88 | EGFR (0.46) | F11RXRATDP1CRHR1CYP3A4 | |
| SCHEMBL6306810 | 0.85 | F11 (0.62) | F11RXRATDP1KDM4E | |
| SCHEMBL6308042 | 0.84 | F11 (0.49) | F11RXRANPSR1DYRK1AHASPIN | |
| SCHEMBL6313461 | 0.83 | F11 (0.41) | F11TDP1HSP90AA1NPSR1CYP1A2 | |
| SCHEMBL7549056 | 0.83 | F11 (0.59) | F11RXRATDP1P2RX3KDM4E | |
| SCHEMBL6308861 | 0.81 | F11 (0.57) | F11RXRATDP1P2RX3KDM4E | |
| SCHEMBL5877056 | 0.81 | CRHR1 (0.43) | F11CRHR1P2RX3HSP90AA1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |