Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7554022 | 0.93 | F11 (0.50) | RXRAKDM4EHSP90AA1NPSR1TDP1 | |
| SCHEMBL6313495 | 0.90 | F11 (0.46) | RXRAALDH1A1MAPK1POLBKDM4E | |
| SCHEMBL6314138 | 0.89 | F11 (0.45) | RXRAPOLBRXFP1TDP1 | |
| SCHEMBL6307883 | 0.89 | EGFR (0.46) | RXRAPOLBRXFP1MEN1KMT2A | |
| SCHEMBL6313886 | 0.86 | ALDH1A1 (0.57) | RXRAALDH1A1MAPK1POLBTSHR | |
| SCHEMBL6308214 | 0.84 | F11 (0.49) | ALDH1A1POLBTSHRRXFP1LMNA | |
| SCHEMBL5877453 | 0.81 | CRHR1 (0.42) | ALDH1A1POLBTSHRRXFP1LMNA | |
| SCHEMBL6308042 | 0.79 | F11 (0.49) | RXRAALDH1A1MAPK1TSHRRXFP1 | |
| SCHEMBL6306810 | 0.78 | F11 (0.62) | RXRAALDH1A1MAPK1POLBTSHR | |
| SCHEMBL6307999 | 0.78 | ALDH1A1 (0.69) | ALDH1A1MAPK1POLBTSHRRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |