Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314138 | 0.93 | F11 (0.45) | EGFRPOLBRXFP1TDP1RXRA | |
| SCHEMBL6313995 | 0.89 | RXRA (0.52) | MEN1KMT2APOLBRXFP1TDP1 | |
| SCHEMBL7554022 | 0.88 | F11 (0.50) | TDP1RXRACYP3A4F11CRHR1 | |
| SCHEMBL6308755 | 0.87 | EGFR (0.56) | EGFRMEN1KMT2APOLBRXFP1 | |
| SCHEMBL6313495 | 0.86 | F11 (0.46) | POLBTDP1RXRAF11CRHR1 | |
| SCHEMBL6307819 | 0.84 | EGFR (0.42) | EGFRMEN1KMT2APOLBRXFP1 | |
| SCHEMBL7550360 | 0.83 | EGFR (0.53) | EGFRMEN1KMT2APOLBRXFP1 | |
| SCHEMBL7488467 | 0.82 | CRHR1 (0.41) | EGFRMEN1KMT2APOLBRXFP1 | |
| SCHEMBL6313852 | 0.80 | EGFR (0.64) | EGFRMEN1KMT2APOLBRXFP1 | |
| SCHEMBL6307218 | 0.80 | F11 (0.55) | EGFRPOLBRXFP1ABCC1F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |