Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7554022 | 0.95 | F11 (0.50) | F11RXRAKDM4ETDP1CRHR1 | |
| SCHEMBL6314138 | 0.91 | F11 (0.45) | F11RXRATDP1POLBCRHR1 | |
| SCHEMBL6313995 | 0.90 | RXRA (0.52) | RXRAALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL6308861 | 0.86 | F11 (0.57) | F11RXRAALDH1A1MAPTHPGD | |
| SCHEMBL6307883 | 0.86 | EGFR (0.46) | F11RXRATDP1POLBCRHR1 | |
| SCHEMBL7554897 | 0.84 | F11 (0.40) | F11ALDH1A1HSP90AA1NPSR1 | |
| SCHEMBL7553290 | 0.83 | F11 (0.52) | F11RXRAALDH1A1MAPTHPGD | |
| SCHEMBL5877936 | 0.82 | CRHR1 (0.41) | F11LMNACRHR1P2RX3 | |
| SCHEMBL6306810 | 0.81 | F11 (0.62) | F11RXRAALDH1A1MAPTHPGD | |
| SCHEMBL6308042 | 0.80 | F11 (0.49) | F11RXRAALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |