Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.37 |
| ▸ | TCF7L2 | Q9NQB0 | 5/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27464341 | 0.92 | CTNNB1 (0.37) | APPCTNNB1TCF7L2MCHR1KMT2A | |
| SCHEMBL6653145 | 0.91 | CTNNB1 (0.36) | APPCTNNB1TCF7L2MCHR1KMT2A | |
| SCHEMBL7553839 | 0.86 | APP (0.49) | APPKMT2AL3MBTL1NTRK1LMNA | |
| SCHEMBL27464342 | 0.82 | SMN1; SMN2 (0.41) | APPCTNNB1TCF7L2MCHR1KMT2A | |
| SCHEMBL7654278 | 0.82 | MEN1 (0.42) | APPCTNNB1TCF7L2KMT2AMEN1 | |
| SCHEMBL6651230 | 0.77 | APP (0.47) | APPKMT2AL3MBTL1MEN1NTRK1 | |
| SCHEMBL6652588 | 0.77 | POLB (0.56) | APPKMT2AL3MBTL1MEN1LMNA | |
| SCHEMBL6655631 | 0.74 | APP (0.44) | APPKMT2AL3MBTL1NTRK1LMNA | |
| SCHEMBL7553111 | 0.73 | APP (0.47) | APPKMT2AL3MBTL1NTRK1LMNA | |
| SCHEMBL28054684 | 0.73 | KDM4E (0.47) | APPKMT2APPARAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218401-A1 | 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE | Aventis Pharma Deutschland GmbH (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021642-A1 | 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-03-29 | — | — | WO | disclosed |