Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 3/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581435 | 0.96 | KMT2A (0.49) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 | |
| SCHEMBL6581923 | 0.94 | NPC1 (0.48) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 | |
| SCHEMBL6581858 | 0.93 | SMN1; SMN2 (0.49) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 | |
| SCHEMBL6582371 | 0.93 | NPC1 (0.49) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 | |
| SCHEMBL6587589 | 0.93 | ALDH1A1 (0.52) | SMN1; SMN2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL7557662 | 0.92 | NPC1 (0.44) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 | |
| SCHEMBL6584628 | 0.92 | PGR (0.47) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 | |
| SCHEMBL6763155 | 0.92 | ALDH1A1 (0.51) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 | |
| SCHEMBL6583333 | 0.92 | KMT2A (0.49) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 | |
| SCHEMBL6584065 | 0.91 | ALDH1A1 (0.51) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194411-A1 | BENZOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001004099-A1 | BENZOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2001-01-18 | — | — | WO | disclosed |