Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7557829 | 0.78 | KMT2A (0.43) | MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL7524755 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL10811051 | 0.68 | MT-CO2 (0.58) | SMN1; SMN2MAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL7517596 | 0.65 | ALDH1A1 (0.54) | SMN1; SMN2MAPK1ALDH1A1RAB9AMEN1 | |
| SCHEMBL2033213 | 0.65 | MT-CO2 (0.69) | SMN1; SMN2MAPK1ALDH1A1RAB9AMEN1 | |
| SCHEMBL1542991 | 0.64 | RAB9A (0.60) | SMN1; SMN2MAPK1ALDH1A1RAB9AMEN1 | |
| Diphenylamine SCHEMBL1619083 | 0.62 | HSD17B10 (1.00) | MAPK1ALDH1A1RAB9AMEN1KMT2A | |
| Diphenylamine SCHEMBL3003404 | 0.62 | HSD17B10 (1.00) | MAPK1ALDH1A1RAB9AMEN1KMT2A | |
| Diphenylamine SCHEMBL229 | 0.62 | HSD17B10 (1.00) | MAPK1ALDH1A1RAB9AMEN1KMT2A | |
| Diphenylamine SCHEMBL301493 | 0.62 | HSD17B10 (1.00) | MAPK1ALDH1A1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173420-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000053581-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2000-09-14 | — | — | WO | disclosed |