Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | PARG | Q86W56 | 5/20 | 0.42 |
| ▸ | LSS | P48449 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460713 | 0.88 | MAPK8 (0.55) | CMA1MAPK8MAPK9HDAC6HDAC1 | |
| SCHEMBL4456863 | 0.88 | GABRA5 (0.53) | CMA1MAPK8MAPK9PARGGABRA5 | |
| SCHEMBL7461329 | 0.86 | CMA1 (0.46) | CMA1MAPK8MAPK9HDAC6HDAC1 | |
| SCHEMBL7459226 | 0.84 | PARG (0.44) | CMA1MAPK8MAPK9HDAC6HDAC1 | |
| SCHEMBL7468517 | 0.84 | HDAC6 (0.52) | CMA1MAPK8MAPK9HDAC6HDAC1 | |
| SCHEMBL7462052 | 0.84 | KMT2A (0.47) | CMA1MAPK8MAPK9HDAC6HDAC1 | |
| SCHEMBL7467427 | 0.83 | ALDH1A1 (0.47) | CMA1MAPK8MAPK9PARGGABRA5 | |
| Iodide SCHEMBL7467165 | 0.82 | CMA1 (0.42) | CMA1MAPK8MAPK9HDAC6HDAC1 | |
| SCHEMBL7468103 | 0.81 | GAA (0.44) | CMA1TP53MAPTHTT | |
| SCHEMBL7472478 | 0.80 | CCR2 (0.50) | CMA1MAPK8MAPK9HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |