Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7564712 | 0.88 | TTR (0.48) | TTRNPSR1LMNAMAPTG6PD | |
| SCHEMBL7562523 | 0.82 | MMP12 (0.42) | — | |
| SCHEMBL7563408 | 0.77 | NPSR1 (0.47) | TTRNPSR1LMNAMAPTMEN1 | |
| SCHEMBL7563386 | 0.76 | NPSR1 (0.43) | NPSR1LMNAMAPTMEN1POLB | |
| SCHEMBL28103034 | 0.76 | LMNA (0.48) | NPSR1LMNAMAPTSIGMAR1HTR2A | |
| SCHEMBL15472268 | 0.75 | TTR (0.55) | TTRNPSR1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7561992 | 0.71 | NPSR1 (0.43) | NPSR1LMNAMAPTMEN1POLB | |
| SCHEMBL5992552 | 0.70 | ALDH1A1 (0.50) | TTRNPSR1LMNAMAPTMEN1 | |
| SCHEMBL7568081 | 0.69 | TTR (0.46) | TTRNPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13719611 | 0.69 | TTR (0.68) | TTRSIGMAR1POLBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882703-B1 | CYCLIC AMIC ACID DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2002-08-14 | — | — | EP | disclosed |
| US-6011174-A | INHIBIT PROTEIN-FARNESYL TRANSFERASE (PFT) IN VIVO THEREBY TO SUPPRESS FUNCTION OF ONCOGENE PROTEIN RAS AND THUS PRESENT ANTITUMOR ACTIVITIES, | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-01-04 | — | — | US | disclosed |
| EP-0882703-A1 | CYCLIC AMIC ACID DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |