Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27456106 | 0.82 | CYP11B1 (0.43) | — | |
| SCHEMBL7543866 | 0.81 | LPL (0.33) | PTGS2PTGS1 | |
| SCHEMBL7624027 | 0.77 | SIGMAR1 (0.34) | PTGS2PTGS1 | |
| SCHEMBL19445334 | 0.69 | NOTUM (0.41) | PGRPTGS2CREBBPNOTUMPTGS1 | |
| SCHEMBL7568643 | 0.66 | PGR (0.35) | PGR | |
| SCHEMBL13741967 | 0.63 | CYP17A1 (0.52) | PGRPTGS2NOTUMPTGS1 | |
| SCHEMBL31158855 | 0.62 | CHRM5 (0.37) | PGRPTGS2CREBBPNOTUMPTGS1 | |
| SCHEMBL7691782 | 0.61 | CYP2A6 (0.35) | PGR | |
| SCHEMBL31158742 | 0.60 | PTGS2 (0.35) | PGRPTGS2CREBBPNOTUMPTGS1 | |
| SCHEMBL6816479 | 0.60 | PCSK9 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175411-A1 | CYCLOTHIOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS | American Home Products Corporation (US) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066570-A1 | CYCLOTHIOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |