Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7572390 | 0.82 | KDM4E (0.58) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL1382258 | 0.82 | ATM (0.56) | KDM4EKMT2AABCB1TSHR | |
| SCHEMBL5365487 | 0.82 | HTR2A (0.47) | PKMALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5366314 | 0.82 | HTR2A (0.47) | PKMALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5365483 | 0.82 | HTR2A (0.47) | PKMALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7569775 | 0.82 | HTR1A (0.53) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL7572169 | 0.81 | PKM (0.57) | PKMALDH1A1KDM4EKMT2AL3MBTL1 | |
| SCHEMBL1381988 | 0.81 | CHRNA7 (0.49) | PKMCHRNA7HTR1ATSHRUSP2 | |
| SCHEMBL1383323 | 0.81 | CHRNA7 (0.49) | PKMCHRNA7HTR1ATSHRUSP2 | |
| SCHEMBL7573958 | 0.81 | CACNA1G (0.48) | KMT2AHTR1ACACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216244-A1 | Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as D4 antagonists | Aventis Pharmaceuticals Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019821-A1 | BENZISOXAZOLYL-, PYRIDOISOXAZOLYL- AND BENZTHIENYL-PHENOXY DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-03-22 | — | — | WO | disclosed |