SCHEMBL7565277

SCHEMBL7565277

Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)n1nnc2ccccc21

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.60
TSHR P16473 4/20 0.59
HSD17B10 Q99714 2/20 0.59
KMT2A Q03164 1/20 0.59
SMN1; SMN2 Q16637 5/20 0.58
SLC9A1 P19634 2/20 0.54
L3MBTL1 Q9Y468 2/20 0.52
POLB P06746 2/20 0.51
GAA P10253 1/20 0.51
TP53 P04637 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
HTT P42858 1/20 0.49
KDM4E B2RXH2 1/20 0.48
LMNA P02545 1/20 0.48
CYP2C19 P33261 1/20 0.48
ALOX5 P09917 1/20 0.47
PDE2A O00408 1/20 0.47
PDE5A O76074 1/20 0.47
CYP3A4 P08684 1/20 0.47
ALOX15 P16050 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7746341 0.84 ALDH1A1 (0.55) ALDH1A1TSHRHSD17B10KMT2ASMN1; SMN2
SCHEMBL11439834 0.81 SLC9A1 (0.70) ALDH1A1TSHRHSD17B10KMT2ASLC9A1
SCHEMBL10541164 0.80 SMN1; SMN2 (0.67) ALDH1A1TSHRHSD17B10KMT2ASMN1; SMN2
SCHEMBL3470648 0.79 ALOX5 (0.75) ALDH1A1TSHRKMT2ASMN1; SMN2L3MBTL1
SCHEMBL3470522 0.79 ALDH3A1 (0.54) ALDH1A1TSHRKMT2ASMN1; SMN2L3MBTL1
SCHEMBL29412576 0.79 ALDH3A1 (0.54) ALDH1A1TSHRKMT2ASMN1; SMN2L3MBTL1
SCHEMBL13265836 0.76 HTT (0.49) ALDH1A1TSHRHSD17B10KMT2ASMN1; SMN2
SCHEMBL13265964 0.76 SMN1; SMN2 (0.52) ALDH1A1TSHRHSD17B10KMT2ASMN1; SMN2
SCHEMBL19911560 0.75 SLC9A1 (0.61) ALDH1A1KMT2ASMN1; SMN2SLC9A1L3MBTL1
SCHEMBL19911567 0.75 SLC9A1 (0.61) ALDH1A1KMT2ASMN1; SMN2SLC9A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6486191-B2 FUNGICIDAL ACTIVITY BAYER AG (DE) 2002-11-26 US disclosed
US-20020094936-A1 Nitrophenyl-sulfonyl-imidazoles and use thereof for controlling vegetable and animal pests ASSMANN LUTZ (DE) 2002-07-18 US disclosed
US-6350770-B1 MICROBIOCIDES, INSECTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2002-02-26 US disclosed
US-20020022728-A1 Nitrophenyl-sulfonyl-imidazoles and use thereof for controlling vegetable and animal pests ASSMANN LUTZ (DE) 2002-02-21 US disclosed
US-6262100-B1 Nitrophenyl-sulfonyl-imidazoles and use thereof for controlling vegetable and animal pests BAYER AKTIENGESELLSCHAFT (DE) 2001-07-17 US disclosed
CN-1264367-A Nitrophenyl-sulfonyl-imidazoles and use thereof for controlling vegetable and animal pests BAYER AG (DE) 2000-08-23 CN disclosed
EP-1003726-A1 NITROPHENYL-SULFONYL-IMIDAZOLES AND USE THEREOF FOR CONTROLLING VEGETABLE AND ANIMAL PESTS Bayer Aktiengesellschaft (DE) 2000-05-31 EP disclosed
WO-1999005116-A1 NITROPHENYL-SULFONYL-IMIDAZOLES AND USE THEREOF FOR CONTROLLING VEGETABLE AND ANIMAL PESTS BAYER AKTIENGESELLSCHAFT (DE) 1999-02-04 WO disclosed
US-4734427-A PLANTS BAYER AKTIENGESELLSCHAFT (DE) 1988-03-29 US disclosed
EP-0238824-A1 Microbicidal agent BAYER AG (DE) 1987-09-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020022728-A1 Nitrophenyl-sulfonyl-imidazoles and use thereof for controlling vegetable and animal pests NOD1, NMRAL1, NAT1 ALDH1A1 2909/4885TSHR 1919/4885HSD17B10 4567/4885
US-20020094936-A1 Nitrophenyl-sulfonyl-imidazoles and use thereof for controlling vegetable and animal pests NOD1, NMRAL1, NAT1 ALDH1A1 2909/4885TSHR 1919/4885HSD17B10 4567/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.