Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11143056 | 0.81 | ALDH1A1 (0.58) | PTGES | |
| SCHEMBL7082105 | 0.78 | NLRP3 (0.50) | — | |
| SCHEMBL9723419 | 0.77 | SOAT2 (0.51) | PTGES | |
| SCHEMBL9386678 | 0.75 | NLRP3 (0.47) | — | |
| SCHEMBL8962491 | 0.74 | KMT2A (0.58) | — | |
| SCHEMBL7568784 | 0.73 | — | — | |
| SCHEMBL6899771 | 0.73 | SOAT1 (0.62) | — | |
| SCHEMBL7080985 | 0.73 | — | — | |
| SCHEMBL7567431 | 0.73 | NLRP3 (0.62) | — | |
| SCHEMBL9765025 | 0.72 | SOAT2 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020183384-A1 | Methods of treating nuclear factor-kappa B mediated diseases and disorders | CORNICELLI JOSEPH ANTHONY (US) | 2002-12-05 | — | — | US | claimed |
| EP-1236468-A1 | Sulfonylaminocarbonyl derivatives for the treatment of nuclear factor-kappa B mediated diseases and disorders | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| EP-0556322-B1 | AMINOSULFONYL UREA ACAT INHIBITORS | WARNER LAMBERT CO (US) | 1996-06-12 | — | — | EP | claimed |
| US-5288757-A | Aminosulfonyl urea ACAT inhibitors and a method of lowering blood cholesterol levels therewith | WARNER-LAMBERT COMPANY (US) | 1994-02-22 | — | — | US | claimed |
| WO-1992008694-A1 | AMINOSULFONYL UREA ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1992-05-29 | — | — | WO | claimed |
| US-20020183384-A1 | Methods of treating nuclear factor-kappa B mediated diseases and disorders | CORNICELLI JOSEPH ANTHONY (US) | 2002-12-05 | — | — | US | disclosed |
| EP-1236468-A1 | Sulfonylaminocarbonyl derivatives for the treatment of nuclear factor-kappa B mediated diseases and disorders | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-0556322-B1 | AMINOSULFONYL UREA ACAT INHIBITORS | WARNER LAMBERT CO (US) | 1996-06-12 | — | — | EP | disclosed |
| US-5288757-A | Aminosulfonyl urea ACAT inhibitors and a method of lowering blood cholesterol levels therewith | WARNER-LAMBERT COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| US-5214206-A | Anticholesterol agents, inhibitors of acylcoenzyme A | WARNER-LAMBERT COMPANY (US) | 1993-05-25 | — | — | US | disclosed |
| WO-1992008694-A1 | AMINOSULFONYL UREA ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1992-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183384-A1 | Methods of treating nuclear factor-kappa B mediated diseases and disorders | NFKBIA, IKBKB, RELA | PTGES 240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.