Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.58 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.56 |
| ▸ | PLAU | P00749 | 1/20 | 0.56 |
| ▸ | TCF4 | P15884 | 1/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL790294 | 0.84 | GAA (0.86) | CYP19A1PKMGAAMAPK1LMNA | |
| SCHEMBL28511460 | 0.83 | GAA (0.73) | CYP19A1PKMGAAMAPK1LMNA | |
| SCHEMBL7590717 | 0.83 | KEAP1 (0.62) | CYP19A1PKMGAAMAPK1LMNA | |
| SCHEMBL8752410 | 0.83 | GAA (0.73) | CYP19A1PKMGAAMAPK1LMNA | |
| SCHEMBL7577405 | 0.83 | PTPRC (0.60) | CYP19A1GAAMAPK1LMNAALDH1A1 | |
| SCHEMBL7573915 | 0.82 | LMNA (0.78) | PKMGAAMAPK1LMNAALDH1A1 | |
| SCHEMBL7573028 | 0.81 | FFAR4 (0.63) | MAPTFFAR4SMN1; SMN2 | |
| SCHEMBL16325591 | 0.80 | PKM (1.00) | CYP19A1PKMGAAMAPK1LMNA | |
| SCHEMBL23109349 | 0.80 | CA1 (0.65) | ALDH1A1MAPTMEN1KMT2AFFAR4 | |
| SCHEMBL32679643 | 0.79 | GAA (0.78) | CYP19A1PKMGAAMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |