Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512320 | 0.85 | NMT2 (0.32) | LMNAPOLBUSP2ALDH1A1MEN1 | |
| SCHEMBL8915668 | 0.75 | HDAC6 (0.37) | USP2HSD17B10HPGDALDH1A1MAPT | |
| SCHEMBL7511671 | 0.73 | HDAC6 (0.39) | USP2HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7512664 | 0.62 | SLC10A2 (0.43) | LMNAUSP2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7574883 | 0.61 | PTGDR2 (0.40) | USP2HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6255214 | 0.56 | TRPA1 (0.40) | HSD17B10HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7761107 | 0.54 | TDP1 (0.63) | LMNAALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL7136977 | 0.54 | ALDH1A1 (0.60) | LMNAHSD17B10HPGDALDH1A1KDM4E | |
| SCHEMBL8949567 | 0.54 | MAPT (0.69) | LMNAPOLBHSD17B10HPGDALDH1A1 | |
| SCHEMBL8319524 | 0.53 | SMN1; SMN2 (0.61) | LMNAHPGDALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608565-B1 | Pyridopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-03-13 | — | — | EP | disclosed |
| US-5654309-A | KIDNEY, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-08-05 | — | — | US | disclosed |