Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568813 | 0.85 | HCAR3 (0.69) | MAPTKMT2AMEN1CRHBPCRHR2 | |
| SCHEMBL9192581 | 0.83 | MAPT (0.64) | MAPTKMT2AMEN1CRHBPCRHR2 | |
| SCHEMBL9043092 | 0.81 | KMT2A (0.72) | MAPTKMT2AMEN1CRHBPCRHR2 | |
| SCHEMBL5591787 | 0.81 | HCAR3 (0.65) | MAPTKMT2ACRHBPCRHR2NPC1 | |
| SCHEMBL7568209 | 0.81 | HDAC3 (0.50) | MAPT | |
| SCHEMBL8396995 | 0.80 | NPC1 (0.72) | MAPTKMT2AMEN1CRHBPCRHR2 | |
| SCHEMBL12388226 | 0.80 | MAPT (0.56) | MAPTKMT2AMEN1CRHBPCRHR2 | |
| SCHEMBL8391902 | 0.77 | MAPT (0.78) | MAPTKMT2AMEN1CRHBPCRHR2 | |
| SCHEMBL9188252 | 0.77 | CASP6 (0.57) | MAPTHCAR3LMNACYP1A2TDP1 | |
| Morpholine SCHEMBL7574967 | 0.76 | HCAR3 (0.55) | MAPTKMT2AMEN1CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0685470-B1 | Benzene derivatives and pharmaceutical composition | KUREHA CHEMICAL IND CO LTD (JP) | 2002-09-11 | — | — | EP | disclosed |
| EP-0685470-A2 | Benzene derivatives and pharmaceutical composition | Kureha Chemical Industry Co., Ltd. (JP) | 1995-12-06 | — | — | EP | disclosed |