Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12388226 | 0.86 | MAPT (0.56) | NPC1RAB9AMAPTLMNAKMT2A | |
| SCHEMBL10977960 | 0.86 | RAB9A (0.63) | NPC1RAB9AMAPTLMNAKMT2A | |
| SCHEMBL7568813 | 0.84 | HCAR3 (0.69) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL8391902 | 0.83 | MAPT (0.78) | NPC1RAB9AMAPTKMT2AMAPK1 | |
| SCHEMBL9043092 | 0.83 | KMT2A (0.72) | NPC1RAB9AMAPTLMNAKMT2A | |
| SCHEMBL9192581 | 0.82 | MAPT (0.64) | NPC1RAB9AMAPTLMNAKMT2A | |
| SCHEMBL31159595 | 0.82 | ALDH1A1 (0.63) | NPC1RAB9AMAPTLMNAKMT2A | |
| SCHEMBL27768183 | 0.82 | RAB9A (0.62) | NPC1RAB9AMAPTLMNAKMT2A | |
| SCHEMBL28619596 | 0.82 | LMNA (0.60) | NPC1RAB9AMAPTLMNAKMT2A | |
| SCHEMBL7572903 | 0.80 | MAPT (0.56) | NPC1RAB9AMAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |