Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7573034 | 0.90 | ACLY (0.53) | ALDH1A1KDM4ETP53HSD11B1TSHR | |
| SCHEMBL7577661 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KDM4ELMNATP53HIF1A | |
| SCHEMBL3777581 | 0.81 | PTGES2 (0.65) | ALDH1A1KDM4ELMNAHIF1AIKBKB | |
| SCHEMBL7569885 | 0.78 | ALDH1A1 (0.59) | ALDH1A1TP53TSHRSLC40A1POLB | |
| SCHEMBL7570489 | 0.78 | LMNA (0.52) | ALDH1A1KDM4ELMNATSHRSMN1; SMN2 | |
| SCHEMBL7588152 | 0.76 | SLC40A1 (0.59) | ALDH1A1TP53HSD11B1TSHRSLC40A1 | |
| SCHEMBL7594250 | 0.76 | SLC40A1 (0.66) | ALDH1A1HSD11B1SLC40A1PKMPOLB | |
| SCHEMBL7594652 | 0.75 | SLC40A1 (0.53) | HSD11B1SLC40A1PKM | |
| SCHEMBL7570349 | 0.74 | ALDH1A1 (0.60) | ALDH1A1KDM4ELMNAHIF1AHTT | |
| SCHEMBL7578595 | 0.74 | NPSR1 (0.72) | ALDH1A1KDM4ELMNATP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |