Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.58 |
| ▸ | EDNRB | P24530 | 2/20 | 0.56 |
| ▸ | EDNRA | P25101 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.50 |
| ▸ | CCR4 | P51679 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7578810 | 0.88 | SLC40A1 (0.64) | SLC40A1HSD11B1EDNRBEDNRAPKM | |
| SCHEMBL7591197 | 0.88 | PTGES2 (0.59) | SLC40A1HSD11B1EDNRBEDNRAPKM | |
| SCHEMBL7594250 | 0.87 | SLC40A1 (0.66) | SLC40A1HSD11B1EDNRBEDNRAPKM | |
| SCHEMBL7594652 | 0.84 | SLC40A1 (0.53) | SLC40A1HSD11B1EDNRBEDNRAPKM | |
| SCHEMBL7591248 | 0.81 | HSD11B1 (0.63) | SLC40A1HSD11B1EDNRBEDNRAPKM | |
| SCHEMBL7596336 | 0.81 | HSD11B1 (0.55) | SLC40A1HSD11B1EDNRBEDNRAPKM | |
| SCHEMBL9931094 | 0.80 | CCR2 (0.74) | PKMTP53CCR2ALDH1A1 | |
| SCHEMBL12407075 | 0.79 | PKM (0.60) | SLC40A1HSD11B1EDNRBEDNRAPKM | |
| SCHEMBL7572387 | 0.79 | SLC40A1 (0.64) | SLC40A1HSD11B1EDNRBEDNRAPTGES2 | |
| SCHEMBL3768958 | 0.79 | HSD11B1 (0.60) | SLC40A1HSD11B1EDNRBEDNRACCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |