Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.55 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5955279 | 0.92 | KEAP1 (0.53) | KEAP1NFE2L2SQSTM1FFAR4LMNA | |
| SCHEMBL7572445 | 0.84 | KEAP1 (0.59) | KEAP1NFE2L2SQSTM1FFAR4LMNA | |
| SCHEMBL5955298 | 0.84 | FFAR4 (0.71) | KEAP1NFE2L2SQSTM1FFAR4LMNA | |
| SCHEMBL7571563 | 0.82 | STAT3 (0.61) | KEAP1NFE2L2SQSTM1FFAR4LMNA | |
| SCHEMBL5956219 | 0.81 | KEAP1 (0.63) | KEAP1NFE2L2SQSTM1FFAR4LMNA | |
| SCHEMBL7597807 | 0.81 | CCR2 (0.71) | LMNACCR2 | |
| SCHEMBL7578507 | 0.80 | KEAP1 (0.53) | KEAP1NFE2L2SQSTM1FFAR4LMNA | |
| SCHEMBL7571600 | 0.80 | CYP2C9 (0.61) | LMNAALDH1A1KMT2ATSHRHTT | |
| SCHEMBL7590023 | 0.79 | CCR2 (0.51) | KEAP1NFE2L2LMNAALDH1A1KMT2A | |
| SCHEMBL7571609 | 0.79 | MAPT (0.54) | KEAP1NFE2L2LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |