Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7597807 | 0.83 | CCR2 (0.71) | CCR2LMNA | |
| SCHEMBL5956006 | 0.83 | KEAP1 (0.58) | KEAP1NFE2L2LMNAMAPTALDH1A1 | |
| SCHEMBL7596280 | 0.81 | CCR2 (0.56) | CCR2KEAP1NFE2L2SMN1; SMN2LMNA | |
| SCHEMBL7588944 | 0.80 | ALDH1A1 (0.56) | CCR2SMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL7573875 | 0.79 | KEAP1 (0.55) | CCR2KEAP1NFE2L2SMN1; SMN2LMNA | |
| SCHEMBL7594380 | 0.79 | KEAP1 (0.62) | KEAP1NFE2L2MEN1TSHRKMT2A | |
| SCHEMBL7591229 | 0.79 | CA12 (0.50) | KEAP1NFE2L2SMN1; SMN2LMNAMAPT | |
| SCHEMBL7590378 | 0.78 | CCR2 (0.48) | CCR2SMN1; SMN2MAPTTP53GAA | |
| SCHEMBL7571609 | 0.78 | MAPT (0.54) | CCR2KEAP1NFE2L2SMN1; SMN2LMNA | |
| SCHEMBL7591285 | 0.77 | SLC40A1 (0.59) | KEAP1NFE2L2LMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |