Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MMP9 | P14780 | 4/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6296941 | 0.89 | NPC1 (0.42) | MEN1KMT2AHPGDALDH1A1NPC1 | |
| SCHEMBL6293053 | 0.88 | MMP2 (0.43) | ALDH1A1NPC1RPS6KA2MMP2MMP9 | |
| SCHEMBL7893148 | 0.79 | SMN1; SMN2 (0.55) | MEN1KMT2AHPGDALDH1A1NPC1 | |
| SCHEMBL7860396 | 0.77 | NPC1 (0.60) | MEN1KMT2AALDH1A1NPC1RPS6KA2 | |
| SCHEMBL7861865 | 0.73 | THRA (0.41) | HPGDGAANPSR1MAPTRAB9A | |
| SCHEMBL30249505 | 0.72 | MMP2 (0.56) | MEN1KMT2AHPGDALDH1A1NPC1 | |
| SCHEMBL4318837 | 0.72 | MMP2 (0.56) | MEN1KMT2AHPGDALDH1A1NPC1 | |
| SCHEMBL9226627 | 0.72 | MEN1 (0.46) | MEN1KMT2ALMNAMAPTRAB9A | |
| SCHEMBL7580305 | 0.69 | HTT (0.45) | MEN1KMT2AHPGDALDH1A1NPC1 | |
| SCHEMBL7862778 | 0.68 | GSK3B (0.59) | MEN1KMT2AALDH1A1NPC1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140768-A1 | USE OF SUBSTITUTED 4-BIARYLBUTYRIC AND 5-BIARYLPENTANOIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | Bayer Aktiengesellschaft (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040539-A1 | USE OF SUBSTITUTED 4-BIARYLBUTYRIC AND 5-BIARYLPENTANOIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-07-13 | — | — | WO | disclosed |