Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.41 |
| ▸ | THRB | P10828 | 7/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861710 | 0.82 | GSK3B (0.49) | NPSR1POLBGAASMN1; SMN2 | |
| SCHEMBL7860396 | 0.73 | NPC1 (0.60) | NPSR1POLBAPEX1HSD17B10TDP1 | |
| SCHEMBL7574583 | 0.73 | MEN1 (0.46) | NPSR1GAAHPGDRAB9AMAPT | |
| SCHEMBL15923472 | 0.72 | RAB9A (0.72) | NPSR1POLBAPEX1HSD17B10TDP1 | |
| SCHEMBL17335414 | 0.72 | RAB9A (0.68) | NPSR1POLBAPEX1HSD17B10TDP1 | |
| SCHEMBL17334629 | 0.72 | HPGD (0.73) | NPSR1POLBAPEX1HSD17B10TDP1 | |
| SCHEMBL7860432 | 0.71 | THRA (0.48) | THRATHRBNPSR1HPGDRAB9A | |
| SCHEMBL7860406 | 0.71 | THRA (0.48) | THRATHRBNPSR1HPGDRAB9A | |
| SCHEMBL7854961 | 0.71 | THRA (0.48) | THRATHRBNPSR1HPGDRAB9A | |
| SCHEMBL7860409 | 0.71 | THRA (0.48) | THRATHRBNPSR1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923529-B1 | SUBSTITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | BAYER AG (US) | 2001-09-19 | — | — | EP | disclosed |
| EP-0923529-A1 | SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | Bayer Corporation (US) | 1999-06-23 | — | — | EP | disclosed |
| US-5863915-A | ENZYME INHIBITORS FOR BONES AND JOINTS | BAYER CORPORATION (US) | 1999-01-26 | — | — | US | disclosed |
| WO-1997043237-A1 | SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | BAYER CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |