Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7574583 | 0.89 | MEN1 (0.46) | NPC1MMP2MMP9ALDH1A1HPGD | |
| SCHEMBL6293053 | 0.88 | MMP2 (0.43) | NPC1MMP2MMP9ALDH1A1GAA | |
| SCHEMBL7860396 | 0.77 | NPC1 (0.60) | NPC1MMP2MMP9ALDH1A1KMT2A | |
| SCHEMBL6292109 | 0.72 | MMP2 (0.51) | NPC1MMP2MMP9ALDH1A1HPGD | |
| SCHEMBL9226627 | 0.72 | MEN1 (0.46) | KDM4EKMT2AHSD17B10POLBMEN1 | |
| SCHEMBL7580305 | 0.69 | HTT (0.45) | NPC1ALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL7862778 | 0.68 | GSK3B (0.59) | NPC1MMP2MMP9ALDH1A1KMT2A | |
| SCHEMBL7861865 | 0.67 | THRA (0.41) | HPGDHSD17B10POLBGAASMN1; SMN2 | |
| SCHEMBL7861710 | 0.67 | GSK3B (0.49) | NPC1MMP2MMP9ALDH1A1KMT2A | |
| SCHEMBL17150420 | 0.67 | KMT2A (0.48) | NPC1ALDH1A1HPGDKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900194-B1 | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases | BAYER AKTIENGESELLSCHAFT (DE) | 2005-05-31 | — | — | US | disclosed |