SCHEMBL7577375

SCHEMBL7577375

Cc1ccc(C(=O)OC(=O)c2ccc(CBr)cc2Br)c(Br)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 1/20 0.44
CYP4A11 Q02928 1/20 0.44
ABL1 P00519 1/20 0.40
RIN1 Q13671 1/20 0.40
MAPT P10636 3/20 0.39
TSHR P16473 2/20 0.39
TP53 P04637 1/20 0.39
ALOX15 P16050 1/20 0.39
MAPK1 P28482 1/20 0.39
KMT2A Q03164 3/20 0.38
THRA P10827 1/20 0.38
THRB P10828 1/20 0.38
HPGD P15428 3/20 0.37
ALDH1A1 P00352 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.35
TDP1 Q9NUW8 1/20 0.35
LMNA P02545 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
KDM4E B2RXH2 1/20 0.35
NPY1R P25929 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7577366 0.84 CSNK2A1 (0.43) CYP4F2CYP4A11ABL1RIN1MAPT
SCHEMBL1754056 0.81 ALDH1A1 (0.46) CYP4F2CYP4A11ABL1MAPTTSHR
SCHEMBL29775267 0.81 ALDH1A1 (0.46) CYP4F2CYP4A11ABL1MAPTTSHR
SCHEMBL20158023 0.77 ABL1 (0.45) CYP4F2CYP4A11ABL1RIN1MAPT
SCHEMBL20157960 0.77 SRD5A2 (0.49) CYP4F2CYP4A11MAPTMAPK1THRA
SCHEMBL20157772 0.77 LOXL2 (0.38) CYP4F2CYP4A11ABL1RIN1MAPT
SCHEMBL20157821 0.77 CYP4F2 (0.46) CYP4F2CYP4A11MAPTTP53KMT2A
SCHEMBL22852761 0.76 TSHR (0.53) CYP4F2CYP4A11MAPTTSHRMAPK1
SCHEMBL30294421 0.76 TSHR (0.53) CYP4F2CYP4A11MAPTTSHRMAPK1
SCHEMBL1770905 0.75 NR4A2 (0.50) ABL1MAPTKMT2AHPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1244678-A1 PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) MERCK FROSST CANADA INC. (CA) 2002-10-02 EP disclosed
EP-1242432-A1 PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) MERCK FROSST CANADA INC. (CA) 2002-09-25 EP disclosed
WO-2001046205-A1 PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) MERCK FROSST CANADA & CO. (CA) 2001-06-28 WO disclosed
WO-2001046206-A1 PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) MERCK FROSST CANADA & CO. (CA) 2001-06-28 WO disclosed