SCHEMBL7577529

SCHEMBL7577529

COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2c(-c3nnn(C)n3)cnn2C)n1.C[C@H](OC(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1Cl)C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.33
LMNA P02545 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
THRB P10828 1/20 0.33
MEN1 O00255 1/20 0.31
TTR P02766 1/20 0.31
PPOX P50336 1/20 0.31
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
FFAR1 O14842 1/20 0.31
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31
KDR P35968 1/20 0.31
SCN9A Q15858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7589011 0.89 MEN1 (0.37) GAALMNAKDM4EMAPTHPGD
Lactofen SCHEMBL7586546 0.87 TDP1 (0.38) GAAMEN1TTRPPOXKMT2A
Acifluorfen SCHEMBL7583316 0.86 TDP1 (0.49) GAALMNAMEN1TTRPPOX
Halosulfuron SCHEMBL7580413 0.85 LMNA (0.36) GAALMNAKDM4EMAPTHPGD
Oxyfluorfen SCHEMBL7579257 0.82 MEN1 (0.38) GAALMNAMAPTTHRBMEN1
SCHEMBL7588064 0.82 TDP1 (0.39) GAATHRBMEN1TTRPPOX
SCHEMBL7596990 0.81 LMNA (0.39) GAALMNAKDM4EMAPTHPGD
SCHEMBL7578313 0.81 NTRK1 (0.36) GAALMNAKDM4EMAPTHPGD
Flupyrsulfuron SCHEMBL7580422 0.80 KMT2A (0.40) GAALMNAKDM4EMAPTHPGD
Flazasulfuron SCHEMBL7578001 0.79 LMNA (0.38) GAALMNAKDM4EMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020004457-A1 Herbicidal composition SYNGENTA PARTICIPATIONS AG (CH) 2002-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020004457-A1 Herbicidal composition PPOX, ALAD, DDT GAA 288/4885LMNA 3881/4885KDM4E 1886/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.