SCHEMBL7578313

SCHEMBL7578313

COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2c(Cl)nc3ccccn23)n1.C[C@H](OC(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1Cl)C(=O)O

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 1/20 0.36
LMNA P02545 3/20 0.35
GAA P10253 2/20 0.35
MAPT P10636 2/20 0.35
KDM4E B2RXH2 1/20 0.35
HPGD P15428 1/20 0.35
THRB P10828 1/20 0.35
FFAR1 O14842 2/20 0.33
MEN1 O00255 1/20 0.33
TTR P02766 1/20 0.33
PPOX P50336 1/20 0.33
KMT2A Q03164 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
RAB9A P51151 2/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
MAPK1 P28482 1/20 0.31
ALDH1A1 P00352 1/20 0.31
EGFR P00533 1/20 0.31
ERBB2 P04626 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sulfosulfuron SCHEMBL7583513 0.93 NTRK1 (0.35) NTRK1LMNAGAAMAPTKDM4E
Halosulfuron SCHEMBL7580413 0.87 LMNA (0.36) LMNAGAAMAPTKDM4EHPGD
Lactofen SCHEMBL7588400 0.86 MEN1 (0.40) NTRK1LMNAGAAMAPTKDM4E
Acifluorfen SCHEMBL7577278 0.85 TDP1 (0.53) NTRK1LMNAGAAMAPTMEN1
SCHEMBL7589011 0.85 MEN1 (0.37) LMNAGAAMAPTKDM4EHPGD
SCHEMBL7596990 0.84 LMNA (0.39) LMNAGAAMAPTKDM4EHPGD
Flupyrsulfuron SCHEMBL7580422 0.83 KMT2A (0.40) LMNAGAAMAPTKDM4EHPGD
Flazasulfuron SCHEMBL7578001 0.83 LMNA (0.38) LMNAGAAMAPTKDM4EHPGD
Fomesafen SCHEMBL7588015 0.82 TDP1 (0.44) NTRK1LMNAGAAMAPTMEN1
SCHEMBL7579452 0.82 MEN1 (0.38) LMNAGAAMAPTKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020004457-A1 Herbicidal composition SYNGENTA PARTICIPATIONS AG (CH) 2002-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020004457-A1 Herbicidal composition PPOX, ALAD, DDT NTRK1 4538/4885LMNA 3881/4885GAA 288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.