Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TACR2 | P21452 | 1/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878366 | 0.83 | ALDH1A1 (0.40) | ALDH1A1MAPTLMNAHIF1AEPAS1 | |
| SCHEMBL7581044 | 0.79 | CDK2 (0.42) | ALDH1A1MAPTLMNAKDM4ETACR2 | |
| SCHEMBL4364501 | 0.76 | EZH2 (0.49) | ALDH1A1MAPTLMNAKDM4EHPGD | |
| SCHEMBL9766726 | 0.71 | ALDH1A1 (0.53) | ALDH1A1MAPTLMNAHIF1AEPAS1 | |
| SCHEMBL4364499 | 0.70 | PDGFRB (0.44) | MAPTKDM4E | |
| SCHEMBL3878362 | 0.64 | TUBB4A (0.39) | ALDH1A1LMNAKDM4ETDP1 | |
| SCHEMBL9766756 | 0.62 | GRIN2D (0.37) | ALDH1A1 | |
| SCHEMBL11714636 | 0.62 | KMT2A (0.41) | ALDH1A1MAPTLMNAKDM4EHPGD | |
| SCHEMBL12687094 | 0.62 | ALDH1A1 (0.42) | ALDH1A1MAPTHIF1AEPAS1 | |
| SCHEMBL12687033 | 0.60 | ALDH1A1 (0.41) | ALDH1A1MAPTHIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686147-B1 | NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | PHARMACIA ITALIA SPA (IT) | 2002-09-25 | — | — | EP | disclosed |
| EP-1241162-A1 | 2,2'-bi-1H-pyrrole derivatives with immunosuppressant activity | Pharmacia Italia S.p.A. (IT) | 2002-09-18 | — | — | EP | disclosed |
| US-5691334-A | IMMUNOMODULATORS FOR SKIN GRAFTS, AUTOIMMUNE AND FOR ORGAN TRANSPLANTS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-11-25 | — | — | US | disclosed |
| EP-0686147-A1 | NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-12-13 | — | — | EP | disclosed |
| WO-1995017381-A1 | NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | PHARMACIA S.P.A. (IT) | 1995-06-29 | — | — | WO | disclosed |