Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | MELK | Q14680 | 1/20 | 0.48 |
| ▸ | KHK | P50053 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28792714 | 0.83 | LMNA (0.53) | ADORA2AADORA1KIF11KDM4ENPC1 | |
| SCHEMBL7591669 | 0.83 | HTR7 (0.67) | HTR3AKHKHTR1AHTR7 | |
| SCHEMBL2385583 | 0.81 | HRH4 (0.55) | MELKACVR1MAPK1ALKMET | |
| SCHEMBL28792803 | 0.80 | HTR7 (0.43) | KDM4ESMN1; SMN2HTR1AHTR7MAPT | |
| SCHEMBL28792806 | 0.79 | ALDH1A1 (0.60) | SMN1; SMN2MAPTMAPK1HTT | |
| SCHEMBL2913155 | 0.77 | MAPT (0.56) | HTR3AADORA2AADORA1ADRA2CKDM4E | |
| SCHEMBL8320347 | 0.77 | ADRB1 (0.63) | HTR3AADRA2CKDM4ENPC1RAB9A | |
| SCHEMBL30108226 | 0.77 | MELK (0.60) | HTR3AMELKADRA2CACVR1KDM4E | |
| SCHEMBL2744322 | 0.77 | CHEK1 (0.61) | KDM4ENPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL30108214 | 0.76 | HTR1A (0.64) | HTR3AADRA2CSMN1; SMN2HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |